to expand the druggable universe
The power of boron
Boron’s unique atomic orbital configurations allow a range of unique chemical interactions with a target. Boron warheads can shift their charge and conformation in different microenvironments as well as bind covalently or non-covalently.
Song Shu et al., Acta Pharm. 2021. Recent developments in the medicinal chemistry of single boron atom-containing compounds.
Reactive’s team harness boron’s powerful chemical capabilities to design improved medicines and pursue previously intractable targets. Boron chemistry expands the druggable universe by bonding to less accessible anchor points as well as shifting its conformation and its charge in the context of binding pockets. Through structure-based drug design, the new bonds on a target provide a path to improved, valuable therapeutics for patients.
PDB crystallography data show that boron warheads bind to above highlighted residues and targets covalently and non-covalently.†
*Yasheen Zhou et al., Abstracts of Papers of the ACS 246, 2013. Benzoxaboroles as high affinity, selective, and safe drug molecules. †Song Shu et al., Acta Pharm. 2021. Recent developments in the medicinal chemistry of single boron atom-containing compounds.
An integrated platform to accelerate discovery of targets and novel boron-based medicines
Our approach is centered around structure-based drug design using our boron chemistry know-how and proprietary computational methods. Our proprietary Reactor platform encompasses: